The immune system has evolved over millions of years as our body’s defense system against pathologic invaders. This learning program is designed to introduce you to the basic functions of the immune system. The program begins with an overview of the types of immune responses: innate immunity as well as antibody-mediated and cell-mediated acquired immunity. You will then learn about ways in which the body can change and shape the immune response as well as the autoimmune responses that can occur when the system for recognizing pathogens malfunctions. Finally you will learn about the specific mechanisms the immune system uses to recognize and destroy tumor cells.
Upon completion of this learning program you will be able to::
Describe innate immunity and its major components.
Define acquired immunity and recall the basics on antigens and antigen-presenting cells.
Identify the different processes and cells involved in antibody-mediated immunity and in cell-mediated immunity.
Describe the mechanisms by which the body can modulate the immune response.
Recognize the basic mechanisms of autoimmune disorders and hypersensitivity reactions.
Summarize the mechanisms of the immune response to tumors
WELCOME
DISCLAIMER
NAVIGATION INSTRUCTIONS
LEARNING OBJECTIVES
TYPES OF IMMUNE RESPONSE
INTRODUCTION
OVERVIEW
INNATE IMMUNITY
Popup: Physical and chemical barriers
Popup: Antimicrobial proteins
Popup: Innate immune cells
Popup: Inflammation
POP QUIZ
ACQUIRED IMMUNITY
Antigens
Antigen-presenting Cells
Major Histocompatibility Complexes
The Major Histocompatibility Complex Class I
Animated Popup: Role of MHC-I molecules in the immune response
The Major Histocompatibility Complex Class II
Pop Quiz
ANTIBODY-MEDIATED IMMUNITY
Antibodies
Antibody Structure
Antibody Classes
Slideshow: Polymeric antibodies
Popup: Immunoglobulin G
Popup: Immunoglobulin A
Popup: Immunoglobulin M
Popup: Immunoglobulin D
Popup: Immunoglobulin E
Pop Quiz
B-Cell Activation
Note:
B-Cell Differentiation and Antibody Production
The Complement System
Complement Activation
Slideshow: The 5 Steps of the complement cascade
Pop Quiz
CELL-MEDIATED IMMUNITY
THE ROLE OF MHC IN CELL-MEDIATED IMMUNITY
T-Cell Activation
Pop Quiz
CD4+ T Cells
Note:
Note:
Note:
CD8+ T Cells
Slideshow: Target cell destruction by CD8+ T cells
PROGRESS CHECK
SECTION SUMMARY
MODULATING THE IMMUNE RESPONSE
CYTOKINES
Note:
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POP QUIZ
IMMUNOLOGIC MEMORY
Memory T Cell Formation
Persistence of Memory T Cells
Memory B Cell Formation
Persistence of Memory B Cells
Pop Quiz
HYPERSENSITIVITY
AUTOIMMUNE DISORDERS
T CELL SELECTION AND IMMUNE TOLERANCE
PROGRESS CHECK
SECTION SUMMARY
TUMOR IMMUNITY
IMMUNODEFICIENCY AND CANCER
ANTI-TUMOR MECHANISMS
Note
Note
Note:
POP QUIZ
TUMOR-SPECIFIC ANTIGENS
TUMOR IMMUNE EVASION
PROGRESS CHECK
SECTION SUMMARY
TEST YOUR ACQUIRED KNOWLEDGE
SUMMARY
FINAL ASSESSMENT
END OF PROGRAM
GLOSSARY
REFERENCES
This course is accredited for continuing education (CE) by the following organizations:
Australian Nursing & Midwifery Federation
CPD Hours: 1
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